Sirt One is a nutritional supplement based on antioxidant active ingredients that react with the Sirt genes in the cell nucleus. These regulate metabolic processes responsible for "cleaning" and renewing cells. Today, the Sirt genes are known as longevity genes. They are responsible for the production of sirtuins, proteins essential for survival that are activated by metabolic stress conditions such as lack of food, stress signals, extreme temperatures, etc.
Sirtuins exert an anti-inflammatory effect that is believed to prevent the onset of chronic degenerative diseases, premature aging and the weakening of the body's natural defenses. The plant world is very rich in micronutrients because plants produce them to defend themselves against the attacks of parasites, bacteria or atmospheric agents. Once they enter the body, they are able to modulate the SIRT genes.
Nowadays we can extract these substances and make them available to the human body.
Sirt One contains green tea polyphenols, specifically EGCG - epigallocatechin gallate, a true ally for a healthy prostate and cardiovascular system. It is a molecule with antiviral and anti-inflammatory properties, also used to prevent certain types of cancer.
Pterostilbene is found mainly in blueberries and red grapes. It is similar to the best known resveratrol, but is more readily available than the latter. By increasing the Nrf2 factor, it increases the activity of various enzymes involved in the protection and detoxification of cells. In addition, it supports cellular apoptosis, has an anti-inflammatory effect thanks to the reduced activity of COX2 and prevents the mechanisms of cellular proliferation.
Resveratrol is a molecule extracted from red grapes. Its potential antitumor and antithrombotic effects remain of particular interest, although its bioavailability when taken orally is low and its clinical usefulness has not yet been definitively confirmed. Its discovery explains the "French paradox", the observation that the French population in the south of France is less prone to cardiovascular problems despite having a diet similar to that of people in some regions of the United States. This benefit has been attributed to the abundant intake of resveratrol in red wine.
Quercetin and hydroxytyrosol are other polyphenols obtained from natural ingredients that have significant anti-radical, anti-inflammatory and neuroprotective effects.
Quercetin is extracted from Sophora Japonica and has a pleiotropic effect that prevents the activity of inflammatory factors such as NFKB, IL6, IL10, COX, LOX. It also helps prevent cell proliferation and reduces glucose absorption in the intestine. It has an immunomodulatory and antibacterial function and is also used as a preventive agent in lung diseases.
Hydroxytyrosol is present in olive oil as oleuropein and has highly antioxidant properties associated with significant neuro- and cardioprotective activity.
Polyphenols, catechins A and B, are also found in extracts of red grapes and maritime pine. They have various properties, including the ability to protect microcirculation and the nervous system.
Finally, broccoli extract is rich in sulforaphane, a chemical compound belonging to the isothiocyanate family, to which numerous studies attribute potential antioxidant and chemopreventive effects on breast, prostate, colon, skin, lung, stomach and bladder tumors.
Sulforaphane works by activating the Nrf2 signaling pathway and NfkB. It modulates the activity of cytochrome P450 and phase II enzymes with detoxifying effects. Studies have confirmed that sulforaphane has increased oral bioavailability.
